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Since the fourth quarter 2007 and continuing throughout 2009, we have significantly reduced clinical development activities on our product candidate pipeline, such that we have limited our expenditures primarily to those required to support our two approved products NitroMisttrade; and Zolpimisttrade; and minor expenditures to support formulation development activities for certain other products, as we did not believe that we had sufficient cash to sustain such activities. Despite this reduction in expenditures for clinical activities, we require capital to sustain our existing organization until such time as clinical activities can be resumed. We received 1,475,000 in gross proceeds on May 30, 2008 from the initial closing of a convertible note financing with certain funds affiliated with ProQuest Investments, and received 2,525,000 in gross proceeds on October 17, 2008, from the subsequent closing of such convertible note financing, collectively referred to herein as the 2008 Financing.

) During 1996, the Indian government monitored the production process by measuring fields and performing periodic crop inspections by local village officials and CBN agents. The government designated village headmen, usually the most productive opium farmers in the local community, to license farmers, to ensure that farmers did not overplant, and to confirm that minimum yields were met.]