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There were no treatment differences by 2 hours after dosing, when 68 to 77 of patients had responded irrespective of treatment. Compared to 50-mg Imigranreg; tablet, at least one dose of NVD-201 also significantly increased percentage of patients who were pain free by 1 to 2 hours post-dosing, with the response ratio indicating significantly faster complete pain relief for the 40-mg dose, and significantly more patients had complete pain relief without use of rescue medication after receiving any dose of NVD-201. In addition, after one or more doses of NVD-201, the percentage of patients who were asymptomatic was significantly increased, and the percentages who experienced nausea, photophobia, or phonophobia were significantly decreased. NVD-201 was comparable to the 100-mg tablet on all the above measures. We believe NVD-201 may provide clinical benefits to migraine sufferers including, possibly, faster relief than Imitrexreg; tablets as well as greater tolerability than triptan nasal sprays.

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