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Estimates of the nature, timing and estimated expenses of the efforts necessary to complete the development of, and the period in which material net cash inflows are expected to commence from, any of our product candidates are subject to numerous risks and uncertainties, including: the scope, rate of progress and expense of our clinical trials and other research and development activities; results of future clinical trials; the expense of clinical trials for additional indications; the terms and timing of any collaborative, licensing and other arrangements that we may establish; the expense and timing of regulatory approvals or changes in the regulatory approval process; the expense of establishing clinical and commercial supplies of our product candidates and any products that we may develop; the effect of competing technologies and market developments; and. the expense of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights. We expect to spend significant amounts on the development of our product candidates and we expect our costs to increase if we restart programs to develop and ultimately commercialize our product candidates.

The Supreme Court has affirmed these powers as an implication of Congresss power to legislate, since the power to investigate is an aspect of Congresss power to legislate, it is as broad as Congresss powers to legislate. However, it is limited to inquiries that are in aid of the legislative function. The courts are highly deferential to Congresss exercise of its investigation powers, Congress has the power to investigate that which it could regulate, and the courts have interpreted Congresss regulatory powers broadly since the Great Depression.]